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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ARHGEF12 All Species: 17.88
Human Site: Y1110 Identified Species: 43.7
UniProt: Q9NZN5 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NZN5 NP_056128.1 1544 173232 Y1110 S D N G A Q I Y E L V A Q T V
Chimpanzee Pan troglodytes XP_001166830 1544 173242 Y1110 S D N G A Q I Y E L V A Q T V
Rhesus Macaque Macaca mulatta XP_001116843 1562 172109 I1096 S K L G P P Q I Y E L V A L T
Dog Lupus familis XP_536546 1708 190894 Y1129 S D N G A Q I Y E L V A Q T V
Cat Felis silvestris
Mouse Mus musculus Q8R4H2 1543 172304 Y1110 S D N G A Q I Y E L V A Q T V
Rat Rattus norvegicus Q9ES67 1527 168515 I1064 S E L G P P Q I Y E L V A L T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505606 1628 182548 Y1165 S E N R A Q I Y E L V A Q T V
Chicken Gallus gallus
Frog Xenopus laevis NP_001082763 1450 164220 Q1035 E D I L V L L Q R Q D D K F N
Zebra Danio Brachydanio rerio XP_001920310 1422 158610 K1008 S W K V N K D K T I E L Y T L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_393610 1768 197046 E1217 T K Y P L L F E N L A K Y T P
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.9 30.8 83 N.A. 89.2 30.5 N.A. 75.6 N.A. 57.8 46.3 N.A. N.A. 22.9 N.A. N.A.
Protein Similarity: 100 99.9 48.9 84.8 N.A. 92.9 48 N.A. 82.3 N.A. 72.2 62.3 N.A. N.A. 41.4 N.A. N.A.
P-Site Identity: 100 100 13.3 100 N.A. 100 13.3 N.A. 86.6 N.A. 6.6 13.3 N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: 100 100 20 100 N.A. 100 26.6 N.A. 93.3 N.A. 20 33.3 N.A. N.A. 20 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 50 0 0 0 0 0 10 50 20 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 50 0 0 0 0 10 0 0 0 10 10 0 0 0 % D
% Glu: 10 20 0 0 0 0 0 10 50 20 10 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 10 0 0 0 0 0 0 10 0 % F
% Gly: 0 0 0 60 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 10 0 0 0 50 20 0 10 0 0 0 0 0 % I
% Lys: 0 20 10 0 0 10 0 10 0 0 0 10 10 0 0 % K
% Leu: 0 0 20 10 10 20 10 0 0 60 20 10 0 20 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 50 0 10 0 0 0 10 0 0 0 0 0 10 % N
% Pro: 0 0 0 10 20 20 0 0 0 0 0 0 0 0 10 % P
% Gln: 0 0 0 0 0 50 20 10 0 10 0 0 50 0 0 % Q
% Arg: 0 0 0 10 0 0 0 0 10 0 0 0 0 0 0 % R
% Ser: 80 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % S
% Thr: 10 0 0 0 0 0 0 0 10 0 0 0 0 70 20 % T
% Val: 0 0 0 10 10 0 0 0 0 0 50 20 0 0 50 % V
% Trp: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 0 0 0 0 50 20 0 0 0 20 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _